Laboratory of Organic Functional (Macro)Molecules
One of main areas of expertise of the Organic Functional Molecules group led by Prof. Guillaume Delaittre deals with the controlled functionalization of materials surfaces. In order to provide specificity and therefore sensitivity to THz-based sensors in terms of pathogen detection, it is important to remove any possible background interference - for instance arising from the adsorption of other proteins or small molecules - so that only analytes of interest lead to a signal. For sensors designed for cell-based investigations it is also important to provide adequate surface properties for the maintenance of cell properties. Both aspects can be tackled by the attachment of functional polymer layers based on brush or hydrogel architectures. The functionality is provided by the incorporation of specific binding sites for the analytes, often in the form of biomolecules.
Publications
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Hetero-Diels–Alder Cycloaddition with RAFT Polymers as Bioconjugation Platform A. Beloqui, S. R. Mane, M. Langer, M. Glassner, D. M. Bauer, L. Fruk, C. Barner-Kowollik,* G. Delaittre* Angew. Chem. Int. Ed. 2020, 45, 19951–19955
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Reactive Block Copolymers for Patterned Surface Immobilization with Sub-30 nm Spacing H. Turgut, N. Dingenouts, V. Trouillet, P. Krolla-Sidenstein, H. Gliemann, G. Delaittre* Polym. Chem. 2019, 10, 1344–1356.
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Nitrilotriacetic Amine-Functionalized Polymeric Core-Shell Nanoparticles as Enzyme Immobilization Supports D. Keller, A. Beloqui, M. Martínez-Martínez, M. Ferrer, G. Delaittre* Biomacromolecules 2017, 18, 2777–2788.
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Guiding Cell Attachment in Three-Dimensional Microscaffolds Selectively Functionalized with Two Distinct Adhesion Proteins B. Richter, V. Hahn, S. Bertels, T. K. Claus, M. Wegener, G. Delaittre,* C. Barner-Kowollik,* M. Bastmeyer* Adv. Mater. 2017, 29, 1604342.
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Single-Molecule Encapsulation: A Straightforward Route to Highly Stable and Printable Enzymes A. Beloqui, S. Baur, V. Trouillet, A. Welle, J. Madsen, M. Bastmeyer, G. Delaittre* Small 2016, 12, 1716–1722.
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Photolithographic Patterning of 3D-Formed Polycarbonate Films for Targeted Cell Guiding A. F. Hirschbiel, S. Geyer, B. Yameen, A. Welle, P. Nikolov, S. Giselbrecht, S. Scholpp,* G. Delaittre,* C. Barner-Kowollik* Adv. Mater. 2015, 27, 2621–2626.
